Cav1.3 L-Type Calcium Channel Dysfunction in Human Disease
نویسندگان
چکیده
منابع مشابه
Calcium Channel Dysfunction in Huntington’s Disease
Huntington’s disease (HD) is an autosomal dominant degenerative disease that is caused by an expansion mutation in the huntingtin protein that lengthens a naturally occurring trinucleotide CAG repeat in exon 1 resulting in striatal degeneration. The mechanism by which striatal neurons undergo selective degeneration is not fully understood, although studies have suggested several different intri...
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The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...
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Cav 1.3 belongs to the family of voltage-gated L-type Ca2+ channels and is encoded by the CACNA1D gene. Cav 1.3 channels are not only essential for cardiac pacemaking, hearing and hormone secretion but are also expressed postsynaptically in neurons, where they shape neuronal firing and plasticity. Recent findings provide evidence that human mutations in the CACNA1D gene can confer risk for the ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.1287